Tumor biology
Group
Head of Group
The group of Dr. Sonja Eberth focuses on transcriptional deregulation in cancer and its impact on the biology of cancer cells, especially in variants of blood cancer, namely leukemia and lymphoma. The deregulation of coding and non-coding genes due to genomic and epigenomic alterations or aberrant signal transduction is a common feature of tumor cells. In contrast to protein-coding genes the molecular mechanisms and factors underlying deregulation of small non-coding RNAs and their relevance for tumorigenesis are still underinvestigated.
With a specific focus on B cell malignancies, the group studies normal and pathologic transcriptional regulation of transcription factors and small non-coding RNAs like microRNAs and aims to resolve their tumor suppressive or -promoting capacities.
